1ghq

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{{STRUCTURE_1ghq| PDB=1ghq | SCENE= }}
{{STRUCTURE_1ghq| PDB=1ghq | SCENE= }}
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'''CR2-C3D COMPLEX STRUCTURE'''
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===CR2-C3D COMPLEX STRUCTURE===
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==Overview==
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Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.
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The line below this paragraph, {{ABSTRACT_PUBMED_11387479}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11387479 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11387479}}
==About this Structure==
==About this Structure==
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[[Category: C3d]]
[[Category: C3d]]
[[Category: Cr2]]
[[Category: Cr2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:34:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:18:13 2008''

Revision as of 02:18, 1 July 2008

Image:1ghq.png

Template:STRUCTURE 1ghq

CR2-C3D COMPLEX STRUCTURE

Template:ABSTRACT PUBMED 11387479

About this Structure

1GHQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of complement receptor 2 in complex with its C3d ligand., Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS, Science. 2001 Jun 1;292(5522):1725-8. PMID:11387479

Page seeded by OCA on Tue Jul 1 05:18:13 2008

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