1gk5

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[[Image:1gk5.gif|left|200px]]
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{{STRUCTURE_1gk5| PDB=1gk5 | SCENE= }}
{{STRUCTURE_1gk5| PDB=1gk5 | SCENE= }}
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'''SOLUTION STRUCTURE THE MEGF/TGFALPHA44-50 CHIMERIC GROWTH FACTOR'''
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===SOLUTION STRUCTURE THE MEGF/TGFALPHA44-50 CHIMERIC GROWTH FACTOR===
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==Overview==
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The solution structure of the growth factor chimera mEGF/TGFalpha44-50 has been determined using an extended version of the dyana procedure for calculating structures from NMR data. The backbone fold and preferred orientation of the domains of the chimera are similar to those found in previous studies of EGF structures, and several H-bonds used as input constraints in those studies were found independently in the chimera. This shows that the modified activity of the chimera does not result from a major structural change. However, the improved precision of the structure presented here allows the origin of some unusual chemical shifts found in all of these compounds to be explained, as well as the results obtained from some site-specific mutants. Further studies of the properties of this chimeric growth factor should help to elucidate the mechanism(s) of hetero- and homodimerization of the c-erbB receptors.
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The line below this paragraph, {{ABSTRACT_PUBMED_11733021}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11733021 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11733021}}
==About this Structure==
==About this Structure==
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1GK5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GK5 OCA].
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1GK5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GK5 OCA].
==Reference==
==Reference==
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[[Category: Chimeric]]
[[Category: Chimeric]]
[[Category: Egf growth factor]]
[[Category: Egf growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:40:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:25:26 2008''

Revision as of 02:25, 1 July 2008

Image:1gk5.png

Template:STRUCTURE 1gk5

SOLUTION STRUCTURE THE MEGF/TGFALPHA44-50 CHIMERIC GROWTH FACTOR

Template:ABSTRACT PUBMED 11733021

About this Structure

1GK5 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of the mEGF/TGFalpha44-50 chimeric growth factor., Chamberlin SG, Brennan L, Puddicombe SM, Davies DE, Turner DL, Eur J Biochem. 2001 Dec;268(23):6247-55. PMID:11733021

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