1gki

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{{STRUCTURE_1gki| PDB=1gki | SCENE= }}
{{STRUCTURE_1gki| PDB=1gki | SCENE= }}
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'''PLASMID COUPLING PROTEIN TRWB IN COMPLEX WITH ADP AND MG2+.'''
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===PLASMID COUPLING PROTEIN TRWB IN COMPLEX WITH ADP AND MG2+.===
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==Overview==
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The transfer of DNA across membranes and between cells is a central biological process; however, its molecular mechanism remains unknown. In prokaryotes, trans-membrane passage by bacterial conjugation, is the main route for horizontal gene transfer. It is the means for rapid acquisition of new genetic information, including antibiotic resistance by pathogens. Trans-kingdom gene transfer from bacteria to plants or fungi and even bacterial sporulation are special cases of conjugation. An integral membrane DNA-binding protein, called TrwB in the Escherichia coli R388 conjugative system, is essential for the conjugation process. This large multimeric protein is responsible for recruiting the relaxosome DNA-protein complex, and participates in the transfer of a single DNA strand during cell mating. Here we report the three-dimensional structure of a soluble variant of TrwB. The molecule consists of two domains: a nucleotide-binding domain of alpha/beta topology, reminiscent of RecA and DNA ring helicases, and an all-alpha domain. Six equivalent protein monomers associate to form an almost spherical quaternary structure that is strikingly similar to F1-ATPase. A central channel, 20 A in width, traverses the hexamer.
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{{ABSTRACT_PUBMED_11214325}}
==About this Structure==
==About this Structure==
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[[Category: F1-atpase-like quaternary structure]]
[[Category: F1-atpase-like quaternary structure]]
[[Category: Ring helicase]]
[[Category: Ring helicase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:41:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:26:24 2008''

Revision as of 02:26, 1 July 2008

Image:1gki.png

Template:STRUCTURE 1gki

PLASMID COUPLING PROTEIN TRWB IN COMPLEX WITH ADP AND MG2+.

Template:ABSTRACT PUBMED 11214325

About this Structure

1GKI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase., Gomis-Ruth FX, Moncalian G, Perez-Luque R, Gonzalez A, Cabezon E, de la Cruz F, Coll M, Nature. 2001 Feb 1;409(6820):637-41. PMID:11214325

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