1gku

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{{STRUCTURE_1gku| PDB=1gku | SCENE= }}
{{STRUCTURE_1gku| PDB=1gku | SCENE= }}
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'''REVERSE GYRASE FROM ARCHAEOGLOBUS FULGIDUS'''
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===REVERSE GYRASE FROM ARCHAEOGLOBUS FULGIDUS===
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==Overview==
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Reverse gyrase is the only topoisomerase known to positively supercoil DNA. The protein appears to be unique to hyperthermophiles, where its activity is believed to protect the genome from denaturation. The 120 kDa enzyme is the only member of the type I topoisomerase family that requires ATP, which is bound and hydrolysed by a helicase-like domain. We have determined the crystal structure of reverse gyrase from Archaeoglobus fulgidus in the presence and absence of nucleotide cofactor. The structure provides the first view of an intact supercoiling enzyme, explains mechanistic differences from other type I topoisomerases and suggests a model for how the two domains of the protein cooperate to positively supercoil DNA. Coordinates have been deposited in the Protein Data Bank under accession codes 1GKU and 1GL9.
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(as it appears on PubMed at http://www.pubmed.gov), where 11823434 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11823434}}
==About this Structure==
==About this Structure==
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[[Category: Helicase]]
[[Category: Helicase]]
[[Category: Topoisomerase]]
[[Category: Topoisomerase]]
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Revision as of 02:27, 1 July 2008

Image:1gku.png

Template:STRUCTURE 1gku

REVERSE GYRASE FROM ARCHAEOGLOBUS FULGIDUS

Template:ABSTRACT PUBMED 11823434

About this Structure

1GKU is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Crystal structure of reverse gyrase: insights into the positive supercoiling of DNA., Rodriguez AC, Stock D, EMBO J. 2002 Feb 1;21(3):418-26. PMID:11823434

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