1gky

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{{STRUCTURE_1gky| PDB=1gky | SCENE= }}
{{STRUCTURE_1gky| PDB=1gky | SCENE= }}
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'''REFINED STRUCTURE OF THE COMPLEX BETWEEN GUANYLATE KINASE AND ITS SUBSTRATE GMP AT 2.0 ANGSTROMS RESOLUTION'''
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===REFINED STRUCTURE OF THE COMPLEX BETWEEN GUANYLATE KINASE AND ITS SUBSTRATE GMP AT 2.0 ANGSTROMS RESOLUTION===
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==Overview==
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The crystal structure of guanylate kinase from Saccharomyces cerevisiae complexed with its substrate GMP has been refined at a resolution of 2.0 A. The final crystallographic R-factor is 17.3% in the resolution range 7.0 A to 2.0 A for all reflections of the 100% complete data set. The final model has standard geometry with root-mean-square deviations of 0.016 A in bond lengths and 3.0 in bond angles. It consists of all 186 amino acid residues, the N-terminal acetyl group, the substrate GMP, one sulfate ion and 174 water molecules. Guanylate kinase is structurally related to adenylate kinases and G-proteins with respect to its central beta-sheet with connecting helices and the giant anion hole that binds nucleoside triphosphates. These nucleotides are ATP and GTP for the kinases and GTP for the G-proteins. The chain segment binding the substrate GMP of guanylate kinase differs grossly from the respective part of the adenylate kinases; it has no counterpart in the G-proteins. The binding mode of GMP is described in detail. Probably, the observed structure represents one of several structurally quite different intermediate states of the catalytic cycle.
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(as it appears on PubMed at http://www.pubmed.gov), where 1314905 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1314905}}
==About this Structure==
==About this Structure==
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[[Category: Stehle, T.]]
[[Category: Stehle, T.]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:42:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:27:33 2008''

Revision as of 02:27, 1 July 2008

Image:1gky.png

Template:STRUCTURE 1gky

REFINED STRUCTURE OF THE COMPLEX BETWEEN GUANYLATE KINASE AND ITS SUBSTRATE GMP AT 2.0 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 1314905

About this Structure

1GKY is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 A resolution., Stehle T, Schulz GE, J Mol Biol. 1992 Apr 20;224(4):1127-41. PMID:1314905

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