1glv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1glv.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1glv.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1glv| PDB=1glv | SCENE= }}
{{STRUCTURE_1glv| PDB=1glv | SCENE= }}
-
'''THREE-DIMENSIONAL STRUCTURE OF THE GLUTATHIONE SYNTHETASE FROM ESCHERICHIA COLI B AT 2.0 ANGSTROMS RESOLUTION'''
+
===THREE-DIMENSIONAL STRUCTURE OF THE GLUTATHIONE SYNTHETASE FROM ESCHERICHIA COLI B AT 2.0 ANGSTROMS RESOLUTION===
-
==Overview==
+
<!--
-
Glutathione synthetase (gamma-L-glutamyl-L-cysteine: glycine ligase (ADP-forming) EC 6.3.2.3: GSHase) catalyzes the synthesis of glutathione from gamma-L-glutamyl-L-cysteine and Gly in the presence of ATP. The enzyme from Escherichia coli is a tetramer with four identical subunits of 316 amino acid residues. The crystal structure of the enzyme has been determined by isomorphous replacement and refined to a 2.0 A resolution. Two regions, Gly164 to Gly167 and Ile226 to Arg241, are invisible on the electron density map. The refined model of the subunit includes 296 amino acid residues and 107 solvent molecules. The crystallographic R-factor is 18.6% for 17.914 reflections with F &gt; 3 sigma between 6.0 A and 2.0 A. The structure consists of three domains: the N-terminal, central, and C-terminal domains. In the tetrameric molecule, two subunits that are in close contact form a tight dimer, two tight dimers forming a tetramer with two solvent regions. The ATP molecule is located in the cleft between the central and C-terminal domains. The ATP binding site is surrounded by two sets of the structural motif that belong to those respective domains. Each motif consists of an anti-parallel beta-sheet and a glycine-rich loop.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8445637}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8445637 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8445637}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Yamaguchi, H.]]
[[Category: Yamaguchi, H.]]
[[Category: Glutathione biosynthesis ligase]]
[[Category: Glutathione biosynthesis ligase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:44:12 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:29:51 2008''

Revision as of 02:29, 1 July 2008

Image:1glv.png

Template:STRUCTURE 1glv

THREE-DIMENSIONAL STRUCTURE OF THE GLUTATHIONE SYNTHETASE FROM ESCHERICHIA COLI B AT 2.0 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8445637

About this Structure

1GLV is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the glutathione synthetase from Escherichia coli B at 2.0 A resolution., Yamaguchi H, Kato H, Hata Y, Nishioka T, Kimura A, Oda J, Katsube Y, J Mol Biol. 1993 Feb 20;229(4):1083-100. PMID:8445637

Page seeded by OCA on Tue Jul 1 05:29:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1glv"
Personal tools