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1gmk

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{{STRUCTURE_1gmk| PDB=1gmk | SCENE= }}
{{STRUCTURE_1gmk| PDB=1gmk | SCENE= }}
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'''GRAMICIDIN/KSCN COMPLEX'''
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===GRAMICIDIN/KSCN COMPLEX===
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==Overview==
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The hydrophobic channel-forming polypeptide gramicidin adopts a left-handed antiparallel double helix conformation with 6.4 residues per turn when in complex with monovalent cation salts in a methanol environment. The crystal structure of the gramicidin/potassium thiocyanate complex (a = 32.06 A, b = 51.80 A, and c = 31.04 A; space group P2(1)2(1)2(1)) has been solved to 2.5 A with an R-factor of 0.193. In the structure, binding sites for the cations are formed by the polypeptide backbone carbonyl groups tilting away from the helix axis toward the ions located in the central lumen. The polypeptide backbone conformations and the side-chain orientations in this potassium complex are significantly different from those in the previously solved gramicidin/caesium chloride crystal complex, due to the requirements for interactions with the smaller sized potassium cation. The locations and numbers of potassium binding sites also differ considerably from the locations and numbers of caesium binding sites in the other structure. Combining information from all the cation binding sites in the two gramicidin/ion complexes produces different views of the three-dimensional structures of a cation as it is transported along a transmembrane pore, and provides an experimental structural basis for modeling the dynamics of peptide-ion binding and ion transport.
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(as it appears on PubMed at http://www.pubmed.gov), where 9086274 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9086274}}
==About this Structure==
==About this Structure==
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[[Category: Membrane ion channel]]
[[Category: Membrane ion channel]]
[[Category: Peptide antibiotic]]
[[Category: Peptide antibiotic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:45:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:31:10 2008''

Revision as of 02:31, 1 July 2008

Image:1gmk.png

Template:STRUCTURE 1gmk

GRAMICIDIN/KSCN COMPLEX

Template:ABSTRACT PUBMED 9086274

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of the gramicidin/potassium thiocyanate complex., Doyle DA, Wallace BA, J Mol Biol. 1997 Mar 14;266(5):963-77. PMID:9086274

Page seeded by OCA on Tue Jul 1 05:31:10 2008

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