1gnd

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{{STRUCTURE_1gnd| PDB=1gnd | SCENE= }}
{{STRUCTURE_1gnd| PDB=1gnd | SCENE= }}
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'''GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM'''
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===GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM===
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==Overview==
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The crystal structure of the bovine alpha-isoform of Rab GDP-dissociation inhibitor (GDI), which functions in vesicle-membrane transport to recycle and regulate Rab GTPases, has been determined to a resolution of 1.81 A. GDI is constructed of two main structural units, a large complex multisheet domain I and a smaller alpha-helical domain II. The structural organization of domain I is surprisingly closely related to FAD-containing monooxygenases and oxidases. Sequence-conserved regions common to GDI and the choroideraemia gene product, which delivers Rab to catalytic subunits of Rab geranylgeranyltransferase II, are clustered on one face of the molecule. The two most sequence-conserved regions, which form a compact structure at the apex of GDI, are shown by site-directed mutagenesis to play a critical role in the binding of Rab proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 8609986 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8609986}}
==About this Structure==
==About this Structure==
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[[Category: Zeng, K.]]
[[Category: Zeng, K.]]
[[Category: Gtpase activation]]
[[Category: Gtpase activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:46:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:33:15 2008''

Revision as of 02:33, 1 July 2008

Image:1gnd.png

Template:STRUCTURE 1gnd

GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM

Template:ABSTRACT PUBMED 8609986

About this Structure

1GND is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure and mutational analysis of Rab GDP-dissociation inhibitor., Schalk I, Zeng K, Wu SK, Stura EA, Matteson J, Huang M, Tandon A, Wilson IA, Balch WE, Nature. 1996 May 2;381(6577):42-8. PMID:8609986

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