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1gp2

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[[Image:1gp2.gif|left|200px]]
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{{Seed}}
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[[Image:1gp2.png|left|200px]]
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{{STRUCTURE_1gp2| PDB=1gp2 | SCENE= }}
{{STRUCTURE_1gp2| PDB=1gp2 | SCENE= }}
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'''G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND'''
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===G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND===
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==Overview==
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The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.
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(as it appears on PubMed at http://www.pubmed.gov), where 8521505 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8521505}}
==About this Structure==
==About this Structure==
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[[Category: Signal transduction protein]]
[[Category: Signal transduction protein]]
[[Category: Wd40]]
[[Category: Wd40]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:50:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:37:42 2008''

Revision as of 02:37, 1 July 2008

Image:1gp2.png

Template:STRUCTURE 1gp2

G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND

Template:ABSTRACT PUBMED 8521505

About this Structure

1GP2 is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2., Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR, Cell. 1995 Dec 15;83(6):1047-58. PMID:8521505

Page seeded by OCA on Tue Jul 1 05:37:42 2008

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