1gp7

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{{STRUCTURE_1gp7| PDB=1gp7 | SCENE= }}
{{STRUCTURE_1gp7| PDB=1gp7 | SCENE= }}
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'''ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH'''
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===ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH===
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==Overview==
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The crystal structure of an acidic phospholipase A(2) from Ophiophagus hannah (king cobra) has been determined by molecular replacement at 2.6-A resolution to a crystallographic R factor of 20.5% (R(free)=23.3%) with reasonable stereochemistry. The venom enzyme contains an unusual "pancreatic loop." The conformation of the loop is well defined and different from those in pancreas PLA(2), showing its structural variability. This analysis provides the first structure of a PLA(2)-type cardiotoxin. The sites related to the cardiotoxic and myotoxic activities are explored and the oligomer observed in the crystalline state is described.
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(as it appears on PubMed at http://www.pubmed.gov), where 12217659 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12217659}}
==About this Structure==
==About this Structure==
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[[Category: Phospholipase a2]]
[[Category: Phospholipase a2]]
[[Category: Snake venom]]
[[Category: Snake venom]]
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Revision as of 02:38, 1 July 2008

Image:1gp7.png

Template:STRUCTURE 1gp7

ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH

Template:ABSTRACT PUBMED 12217659

About this Structure

1GP7 is a Single protein structure of sequence from Ophiophagus hannah. Full crystallographic information is available from OCA.

Reference

Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop"., Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ, J Struct Biol. 2002 Jun;138(3):207-15. PMID:12217659

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