1gpj

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{{STRUCTURE_1gpj| PDB=1gpj | SCENE= }}
{{STRUCTURE_1gpj| PDB=1gpj | SCENE= }}
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'''GLUTAMYL-TRNA REDUCTASE FROM METHANOPYRUS KANDLERI'''
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===GLUTAMYL-TRNA REDUCTASE FROM METHANOPYRUS KANDLERI===
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==Overview==
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Processes vital to life such as respiration and photosynthesis critically depend on the availability of tetrapyrroles including hemes and chlorophylls. tRNA-dependent catalysis generally is associated with protein biosynthesis. An exception is the reduction of glutamyl-tRNA to glutamate-1-semialdehyde by the enzyme glutamyl-tRNA reductase. This reaction is the indispensable initiating step of tetrapyrrole biosynthesis in plants and most prokaryotes. The crystal structure of glutamyl-tRNA reductase from the archaeon Methanopyrus kandleri in complex with the substrate-like inhibitor glutamycin at 1.9 A resolution reveals an extended yet planar V-shaped dimer. The well defined interactions of the inhibitor with the active site support a thioester-mediated reduction process. Modeling the glutamyl-tRNA onto each monomer reveals an extensive protein-tRNA interface. We furthermore propose a model whereby the large void of glutamyl-tRNA reductase is occupied by glutamate-1-semialdehyde-1,2-mutase, the subsequent enzyme of this pathway, allowing for the efficient synthesis of 5-aminolevulinic acid, the common precursor of all tetrapyrroles.
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(as it appears on PubMed at http://www.pubmed.gov), where 11726494 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11726494}}
==About this Structure==
==About this Structure==
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[[Category: Glutamyl trna-reductase]]
[[Category: Glutamyl trna-reductase]]
[[Category: Trna-dependent tetrapyrrole biosynthesis]]
[[Category: Trna-dependent tetrapyrrole biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:51:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:39:18 2008''

Revision as of 02:39, 1 July 2008

Image:1gpj.png

Template:STRUCTURE 1gpj

GLUTAMYL-TRNA REDUCTASE FROM METHANOPYRUS KANDLERI

Template:ABSTRACT PUBMED 11726494

About this Structure

1GPJ is a Single protein structure of sequence from Methanopyrus kandleri. Full crystallographic information is available from OCA.

Reference

V-shaped structure of glutamyl-tRNA reductase, the first enzyme of tRNA-dependent tetrapyrrole biosynthesis., Moser J, Schubert WD, Beier V, Bringemeier I, Jahn D, Heinz DW, EMBO J. 2001 Dec 3;20(23):6583-90. PMID:11726494

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