1gqv

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{{STRUCTURE_1gqv| PDB=1gqv | SCENE= }}
{{STRUCTURE_1gqv| PDB=1gqv | SCENE= }}
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'''ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN'''
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===ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN===
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==Overview==
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Human eosinophil-derived neurotoxin (EDN) is a small, basic protein that belongs to the ribonuclease A superfamily. EDN displays antiviral activity and causes the neurotoxic Gordon phenomenon when injected into rabbits. Although EDN and ribonuclease A have appreciable structural similarity and a conserved catalytic triad, their peripheral substrate-binding sites are not conserved. The crystal structure of recombinant EDN (rEDN) has been determined at 0.98 A resolution from data collected at a low temperature (100 K). We have refined the crystallographic model of the structure using anisotropic displacement parameters to a conventional R-factor of 0.116. This represents the highest resolution structure of rEDN determined to date and is only the second ribonuclease structure to be determined at a resolution greater than 1.0 A. The structure provides a detailed picture of the conformational freedom at the various subsites of rEDN, and the water structure accounts for more than 50% of the total solvent content of the unit cell. This information will be crucial for the design of tight-binding inhibitors to restrain the ribonucleolytic activity of rEDN.
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The line below this paragraph, {{ABSTRACT_PUBMED_11876642}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11876642 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11876642}}
==About this Structure==
==About this Structure==
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[[Category: Rnase us]]
[[Category: Rnase us]]
[[Category: Rnase-2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:54:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:55:34 2008''

Revision as of 02:55, 1 July 2008

Image:1gqv.png

Template:STRUCTURE 1gqv

ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN

Template:ABSTRACT PUBMED 11876642

About this Structure

1GQV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Atomic resolution (0.98 A) structure of eosinophil-derived neurotoxin., Swaminathan GJ, Holloway DE, Veluraja K, Acharya KR, Biochemistry. 2002 Mar 12;41(10):3341-52. PMID:11876642

Page seeded by OCA on Tue Jul 1 05:55:34 2008

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