This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1grz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1grz.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1grz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1grz| PDB=1grz | SCENE= }}
{{STRUCTURE_1grz| PDB=1grz | SCENE= }}
-
'''A PREORGANIZED ACTIVE SITE IN THE CRYSTAL STRUCTURE OF THE TETRAHYMENA RIBOZYME'''
+
===A PREORGANIZED ACTIVE SITE IN THE CRYSTAL STRUCTURE OF THE TETRAHYMENA RIBOZYME===
-
==Overview==
+
<!--
-
Group I introns possess a single active site that catalyzes the two sequential reactions of self-splicing. An RNA comprising the two domains of the Tetrahymena thermophila group I intron catalytic core retains activity, and the 5.0 angstrom crystal structure of this 247-nucleotide ribozyme is now described. Close packing of the two domains forms a shallow cleft capable of binding the short helix that contains the 5' splice site. The helix that provides the binding site for the guanosine substrate deviates significantly from A-form geometry, providing a tight binding pocket. The binding pockets for both the 5' splice site helix and guanosine are formed and oriented in the absence of these substrates. Thus, this large ribozyme is largely preorganized for catalysis, much like a globular protein enzyme.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9841391}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9841391 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9841391}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Ribozyme structure]]
[[Category: Ribozyme structure]]
[[Category: Rrna group i intron]]
[[Category: Rrna group i intron]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:56:18 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:58:38 2008''

Revision as of 02:58, 1 July 2008

Image:1grz.png

Template:STRUCTURE 1grz

A PREORGANIZED ACTIVE SITE IN THE CRYSTAL STRUCTURE OF THE TETRAHYMENA RIBOZYME

Template:ABSTRACT PUBMED 9841391

About this Structure

Full crystallographic information is available from OCA.

Reference

A preorganized active site in the crystal structure of the Tetrahymena ribozyme., Golden BL, Gooding AR, Podell ER, Cech TR, Science. 1998 Oct 9;282(5387):259-64. PMID:9841391

Page seeded by OCA on Tue Jul 1 05:58:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1grz"
Personal tools