1gs0

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{{STRUCTURE_1gs0| PDB=1gs0 | SCENE= }}
{{STRUCTURE_1gs0| PDB=1gs0 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF MURINE POLY (ADP-RIBOSE) POLYMERASE-2'''
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===CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF MURINE POLY (ADP-RIBOSE) POLYMERASE-2===
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==Overview==
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Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important pharmacological target in the treatment of cancer due to its cellular role as a 'DNA-strand break sensor', which leads in part to resistance to some existing chemo- and radiological treatments. Inhibitors have now been developed which prevent PARP-1 from synthesizing poly(ADP-ribose) in response to DNA-breaks and potentiate the cytotoxicity of DNA damaging agents. However, with the recent discoveries of PARP-2, which has a similar DNA-damage dependent catalytic activity, and additional members containing the 'PARP catalytic' signature, the isoform selectivity and resultant pharmacological effects of existing inhibitors are brought into question. We present here the crystal structure of the catalytic fragment of murine PARP-2, at 2.8 A resolution, and compare this to the catalytic fragment of PARP-1, with an emphasis on providing a possible framework for rational drug design in order to develop future isoform-specific inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 14739238 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14739238}}
==About this Structure==
==About this Structure==
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[[Category: Nuclear protein]]
[[Category: Nuclear protein]]
[[Category: Polymerase transferase]]
[[Category: Polymerase transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:56:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:58:42 2008''

Revision as of 02:58, 1 July 2008

Image:1gs0.png

Template:STRUCTURE 1gs0

CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF MURINE POLY (ADP-RIBOSE) POLYMERASE-2

Template:ABSTRACT PUBMED 14739238

About this Structure

1GS0 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2., Oliver AW, Ame JC, Roe SM, Good V, de Murcia G, Pearl LH, Nucleic Acids Res. 2004 Jan 22;32(2):456-64. Print 2004. PMID:14739238

Page seeded by OCA on Tue Jul 1 05:58:42 2008

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