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1gsd

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{{STRUCTURE_1gsd| PDB=1gsd | SCENE= }}
{{STRUCTURE_1gsd| PDB=1gsd | SCENE= }}
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'''GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM'''
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===GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM===
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==Overview==
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BACKGROUND: Glutathione transferases (GSTs) constitute a family of isoenzymes that catalyze the conjugation of the tripeptide glutathione with a wide variety of hydrophobic compounds bearing an electrophilic functional group. Recently, a number of X-ray structures have been reported which have defined both the glutathione- and the substrate-binding sites in these enzymes. The structure of the glutathione-free enzyme from a mammalian source has not, however, been reported previously. RESULTS: We have solved structures of a human alpha-class GST, isoenzyme A1-1, both in the unliganded form and in complexes with the inhibitor ethacrynic acid and its glutathione conjugate. These structures have been refined to resolutions of 2.5 A, 2.7 A and 2.0 A respectively. Both forms of the inhibitor are clearly present in the associated electron density. CONCLUSIONS: The major differences among the three structures reported here involve the C-terminal alpha-helix, which is a characteristic of the alpha-class enzyme. This helix forms a lid over the active site when the hydrophobic substrate binding site (H-site) is occupied but it is otherwise disordered. Ethacrynic acid appears to bind in a non-productive mode in the absence of the coenzyme glutathione.
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(as it appears on PubMed at http://www.pubmed.gov), where 8591048 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8591048}}
==About this Structure==
==About this Structure==
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[[Category: Jones, T A.]]
[[Category: Jones, T A.]]
[[Category: Sinning, I.]]
[[Category: Sinning, I.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:56:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:59:39 2008''

Revision as of 02:59, 1 July 2008

Image:1gsd.png

Template:STRUCTURE 1gsd

GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM

Template:ABSTRACT PUBMED 8591048

About this Structure

1GSD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate., Cameron AD, Sinning I, L'Hermite G, Olin B, Board PG, Mannervik B, Jones TA, Structure. 1995 Jul 15;3(7):717-27. PMID:8591048

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