4rhn
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="4rhn" size="450" color="white" frame="true" align="right" spinBox="true" caption="4rhn, resolution 1.90Å" /> '''HISTIDINE TRIAD NUC...)
Next diff →
Revision as of 17:47, 29 October 2007
|
HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH ADENOSINE
Overview
Histidine triad nucleotide-binding protein (HINT), a dimeric purine, nucleotide-binding protein from rabbit heart, is a member of the HIT, (histidine triad) superfamily which includes HINT homologues and FHIT (HIT, protein encoded at the chromosome 3 fragile site) homologues. Crystal, structures of HINT-nucleotide complexes demonstrate that the most, conserved residues in the superfamily mediate nucleotide binding and that, the HIT motif forms part of the phosphate binding loop., Galactose-1-phosphate uridylyltransferase, whose deficiency causes, galactosemia, contains tandem HINT domains with the same fold and mode of, nucleotide binding as HINT despite having no overall sequence similarity., Features of FHIT, a diadenosine polyphosphate hydrolase and candidate, tumour suppressor, are ... [(full description)]
About this Structure
4RHN is a [Single protein] structure of sequence from [Oryctolagus cuniculus] with RIB as [ligand]. Full crystallographic information is available from [OCA].
Reference
Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins., Brenner C, Garrison P, Gilmour J, Peisach D, Ringe D, Petsko GA, Lowenstein JM, Nat Struct Biol. 1997 Mar;4(3):231-8. PMID:9164465
Page seeded by OCA on Mon Oct 29 19:51:42 2007
