This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1guf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1guf.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1guf.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1guf| PDB=1guf | SCENE= }}
{{STRUCTURE_1guf| PDB=1guf | SCENE= }}
-
'''ENOYL THIOESTER REDUCTASE FROM CANDIDA TROPICALIS'''
+
===ENOYL THIOESTER REDUCTASE FROM CANDIDA TROPICALIS===
-
==Overview==
+
<!--
-
Candida tropicalis enoyl thioester reductase Etr1p and the Saccharomyces cerevisiae homologue Mrf1p catalyse the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (FAS). Unlike prokaryotic enoyl thioester reductases (ETRs), which belong to the short-chain dehydrogenases/reductases (SDR), Etr1p and Mrf1p represent structurally distinguishable ETRs that belong to the medium-chain dehydrogenases/reductases (MDR) superfamily, indicating independent origin of two separate classes of ETRs. The crystal structures of Etr1p, the Etr1p-NADPH complex and the Etr1Y79Np mutant were refined to 1.70A, 2.25A and 2.60A resolution, respectively. The native fold of Etr1p was maintained in Etr1Y79Np, but the mutant had only 0.1% of Etr1p catalytic activity remaining and failed to rescue the respiratory deficient phenotype of the mrf1Delta strain. Mutagenesis of Tyr73 in Mrf1p, corresponding to Tyr79 in Etr1p, produced similar results. Our data indicate that the mitochondrial reductase activity is indispensable for respiratory function in yeast, emphasizing the significance of Mrf1p (Etr1p) and mitochondrial FAS for the integrity of the respiratory competent organelle.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12614607}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12614607 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12614607}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Wierenga, R K.]]
[[Category: Wierenga, R K.]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:01:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:05:51 2008''

Revision as of 03:05, 1 July 2008

Image:1guf.png

Template:STRUCTURE 1guf

ENOYL THIOESTER REDUCTASE FROM CANDIDA TROPICALIS

Template:ABSTRACT PUBMED 12614607

About this Structure

1GUF is a Single protein structure of sequence from Candida tropicalis. Full crystallographic information is available from OCA.

Reference

Structure-function analysis of enoyl thioester reductase involved in mitochondrial maintenance., Airenne TT, Torkko JM, Van den plas S, Sormunen RT, Kastaniotis AJ, Wierenga RK, Hiltunen JK, J Mol Biol. 2003 Mar 14;327(1):47-59. PMID:12614607

Page seeded by OCA on Tue Jul 1 06:05:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1guf"
Personal tools