1guk

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{{STRUCTURE_1guk| PDB=1guk | SCENE= }}
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'''CRYSTAL STRUCTURE OF MURINE ALPHA-CLASS GSTA4-4'''
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===CRYSTAL STRUCTURE OF MURINE ALPHA-CLASS GSTA4-4===
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==Overview==
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Glutathione S-transferases (GSTs) are ubiquitous multifunctional enzymes which play a key role in cellular detoxification. The enzymes protect the cells against toxicants by conjugating them to glutathione. Recently, a novel subgroup of alpha-class GSTs has been identified with altered substrate specificity which is particularly important for cellular defense against oxidative stress. Here, we report the crystal structure of murine GSTA4-4, which is the first structure of a prototypical member of this subgroup. The structure was solved by molecular replacement and refined to 2.9 A resolution. It resembles the structure of other members of the GST superfamily, but reveals a distinct substrate binding site.
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{{ABSTRACT_PUBMED_9498801}}
==About this Structure==
==About this Structure==
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[[Category: Oxidative stress]]
[[Category: Oxidative stress]]
[[Category: Transferase]]
[[Category: Transferase]]
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Revision as of 03:06, 1 July 2008

Image:1guk.png

Template:STRUCTURE 1guk

CRYSTAL STRUCTURE OF MURINE ALPHA-CLASS GSTA4-4

Template:ABSTRACT PUBMED 9498801

About this Structure

1GUK is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a murine alpha-class glutathione S-transferase involved in cellular defense against oxidative stress., Krengel U, Schroter KH, Hoier H, Arkema A, Kalk KH, Zimniak P, Dijkstra BW, FEBS Lett. 1998 Feb 6;422(3):285-90. PMID:9498801

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