1gv9

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{{STRUCTURE_1gv9| PDB=1gv9 | SCENE= }}
{{STRUCTURE_1gv9| PDB=1gv9 | SCENE= }}
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'''P58/ERGIC-53'''
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===P58/ERGIC-53===
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==Overview==
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p58/ERGIC-53 is an animal calcium-dependent lectin that cycles between the endoplasmic reticulum (ER) and the Golgi complex and appears to act as a cargo receptor for a subset of soluble glycoproteins exported from the ER. We have determined the crystal structure of the carbohydrate recognition domain (CRD) of p58, the rat homologue of human ERGIC-53, to 1.46 A resolution. The fold and ligand binding site are most similar to those of leguminous lectins. The structure also resembles that of the CRD of the ER folding chaperone calnexin and the neurexins, a family of non-lectin proteins expressed on neurons. The CRD comprises one concave and one convex beta-sheet packed into a beta-sandwich. The ligand binding site resides in a negatively charged cleft formed by conserved residues. A large surface patch of conserved residues with a putative role in protein-protein interactions and oligomerization lies on the opposite side of the ligand binding site. Together with previous functional data, the structure defines a new and expanding class of calcium-dependent animal lectins and provides a starting point for the understanding of glycoprotein sorting between the ER and the Golgi.
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(as it appears on PubMed at http://www.pubmed.gov), where 11850423 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11850423}}
==About this Structure==
==About this Structure==
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[[Category: Carbohydrate binding]]
[[Category: Carbohydrate binding]]
[[Category: Lectin]]
[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:03:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:08:29 2008''

Revision as of 03:08, 1 July 2008

Image:1gv9.png

Template:STRUCTURE 1gv9

P58/ERGIC-53

Template:ABSTRACT PUBMED 11850423

About this Structure

1GV9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the carbohydrate recognition domain of p58/ERGIC-53, a protein involved in glycoprotein export from the endoplasmic reticulum., Velloso LM, Svensson K, Schneider G, Pettersson RF, Lindqvist Y, J Biol Chem. 2002 May 3;277(18):15979-84. Epub 2002 Feb 15. PMID:11850423

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