1gx3

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{{STRUCTURE_1gx3| PDB=1gx3 | SCENE= }}
{{STRUCTURE_1gx3| PDB=1gx3 | SCENE= }}
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'''M. SMEGMATIS ARYLAMINE N-ACETYL TRANSFERASE'''
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===M. SMEGMATIS ARYLAMINE N-ACETYL TRANSFERASE===
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==Overview==
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Arylamine N-acetyltransferases which acetylate and inactivate isoniazid, an anti-tubercular drug, are found in mycobacteria including Mycobacterium smegmatis and Mycobacterium tuberculosis. We have solved the structure of arylamine N-acetyltransferase from M. smegmatis at a resolution of 1.7 A as a model for the highly homologous NAT from M. tuberculosis. The fold closely resembles that of NAT from Salmonella typhimurium, with a common catalytic triad and domain structure that is similar to certain cysteine proteases. The detailed geometry of the catalytic triad is typical of enzymes which use primary alcohols or thiols as activated nucleophiles. Thermal mobility and structural variations identify parts of NAT which might undergo conformational changes during catalysis. Sequence conservation among eubacterial NATs is restricted to structural residues of the protein core, as well as the active site and a hinge that connects the first two domains of the NAT structure. The structure of M. smegmatis NAT provides a template for modelling the structure of the M. tuberculosis enzyme and for structure-based ligand design as an approach to designing anti-TB drugs.
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(as it appears on PubMed at http://www.pubmed.gov), where 12054803 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12054803}}
==About this Structure==
==About this Structure==
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[[Category: Mycobacteria]]
[[Category: Mycobacteria]]
[[Category: Nat]]
[[Category: Nat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:15:08 2008''

Revision as of 03:15, 1 July 2008

Image:1gx3.png

Template:STRUCTURE 1gx3

M. SMEGMATIS ARYLAMINE N-ACETYL TRANSFERASE

Template:ABSTRACT PUBMED 12054803

About this Structure

1GX3 is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.

Reference

The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid., Sandy J, Mushtaq A, Kawamura A, Sinclair J, Sim E, Noble M, J Mol Biol. 2002 May 10;318(4):1071-83. PMID:12054803

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