1gya

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[[Image:1gya.gif|left|200px]]
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{{STRUCTURE_1gya| PDB=1gya | SCENE= }}
{{STRUCTURE_1gya| PDB=1gya | SCENE= }}
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'''N-GLYCAN AND POLYPEPTIDE NMR SOLUTION STRUCTURES OF THE ADHESION DOMAIN OF HUMAN CD2'''
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===N-GLYCAN AND POLYPEPTIDE NMR SOLUTION STRUCTURES OF THE ADHESION DOMAIN OF HUMAN CD2===
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==Overview==
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The adhesion domain of human CD2 bears a single N-linked carbohydrate. The solution structure of a fragment of CD2 containing the covalently bound high-mannose N-glycan [-(N-acetylglucosamine)2-(mannose)5-8] was solved by nuclear magnetic resonance. The stem and two of three branches of the carbohydrate structure are well defined and the mobility of proximal glycan residues is restricted. Mutagenesis of all residues in the vicinity of the glycan suggests that the glycan is not a component of the CD2-CD58 interface; rather, the carbohydrate stabilizes the protein fold by counterbalancing an unfavorable clustering of five positive charges centered about lysine-61 of CD2.
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(as it appears on PubMed at http://www.pubmed.gov), where 7544493 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7544493}}
==About this Structure==
==About this Structure==
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1GYA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYA OCA].
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1GYA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYA OCA].
==Reference==
==Reference==
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[[Category: Immunoglobulin superfamily v-set domain]]
[[Category: Immunoglobulin superfamily v-set domain]]
[[Category: T lymphocyte adhesion glycoprotein]]
[[Category: T lymphocyte adhesion glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:18:34 2008''

Revision as of 03:18, 1 July 2008

Image:1gya.png

Template:STRUCTURE 1gya

N-GLYCAN AND POLYPEPTIDE NMR SOLUTION STRUCTURES OF THE ADHESION DOMAIN OF HUMAN CD2

Template:ABSTRACT PUBMED 7544493

About this Structure

1GYA is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Conformation and function of the N-linked glycan in the adhesion domain of human CD2., Wyss DF, Choi JS, Li J, Knoppers MH, Willis KJ, Arulanandam AR, Smolyar A, Reinherz EL, Wagner G, Science. 1995 Sep 1;269(5228):1273-8. PMID:7544493

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