1gyv

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{{STRUCTURE_1gyv| PDB=1gyv | SCENE= }}
{{STRUCTURE_1gyv| PDB=1gyv | SCENE= }}
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'''GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1, L762E MUTANT'''
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===GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1, L762E MUTANT===
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==Overview==
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The AP1 complex is one of a family of heterotetrameric clathrin-adaptor complexes involved in vesicular trafficking between the Golgi and endosomes. The complex has two large subunits, gamma and beta1, which can be divided into trunk, hinge, and appendage domains. The 1.8 A resolution structure of the gamma appendage is presented. The binding site for the known gamma appendage ligand gamma-synergin is mapped through creation of point mutations designed on the basis of the structure. We also show that Eps15, a protein believed to be involved in vesicle formation at the plasma membrane, is also a ligand of gamma appendage and binds to the same site as gamma-synergin. This observation explains the demonstrated brefeldinA (BFA)-sensitive colocalization of Eps15 and AP1 at the Golgi complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 12176391 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12176391}}
==About this Structure==
==About this Structure==
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[[Category: Endocytosis]]
[[Category: Endocytosis]]
[[Category: Golgi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:20:08 2008''

Revision as of 03:20, 1 July 2008

Image:1gyv.png

Template:STRUCTURE 1gyv

GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1, L762E MUTANT

Template:ABSTRACT PUBMED 12176391

About this Structure

1GYV is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin., Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ, Structure. 2002 Aug;10(8):1139-48. PMID:12176391

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