1gyz

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[[Image:1gyz.gif|left|200px]]
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{{STRUCTURE_1gyz| PDB=1gyz | SCENE= }}
{{STRUCTURE_1gyz| PDB=1gyz | SCENE= }}
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'''BACTERIAL RIBOSOMAL PROTEIN L20 FROM AQUIFEX AEOLICUS'''
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===BACTERIAL RIBOSOMAL PROTEIN L20 FROM AQUIFEX AEOLICUS===
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==Overview==
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L20 is a specific protein of the bacterial ribosome, which is involved in the early assembly steps of the 50S subunit and in the feedback control of the expression of its own gene. This dual function involves specific interactions with either the 23S rRNA or its messenger RNA. The solution structure of the free Aquifex aeolicus L20 has been solved. It is composed of an unstructured N-terminal domain comprising residues 1-58 and a C-terminal alpha-helical domain. This is in contrast with what is observed in the bacterial 50S subunit, where the N-terminal region folds as an elongated alpha-helical region. The solution structure of the C-terminal domain shows that several solvent-accessible, conserved residues are clustered on the surface of the molecule and are probably involved in RNA recognition. In vivo studies show that this domain is sufficient to repress the expression of the cistrons encoding L35 and L20 in the IF3 operon. The ability of L20 C-terminal domain to specifically recognise RNA suggests an assembly mechanism for L20 into the ribosome. The pre-folded C-terminal domain would make a primary interaction with a specific site on the 23S rRNA. The N-terminal domain would then fold within the ribosome, participating in its correct 3D assembly.
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(as it appears on PubMed at http://www.pubmed.gov), where 12368106 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12368106}}
==About this Structure==
==About this Structure==
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1GYZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYZ OCA].
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1GYZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYZ OCA].
==Reference==
==Reference==
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[[Category: Rrna-binding]]
[[Category: Rrna-binding]]
[[Category: Translational control]]
[[Category: Translational control]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:11:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:20:24 2008''

Revision as of 03:20, 1 July 2008

Image:1gyz.png

Template:STRUCTURE 1gyz

BACTERIAL RIBOSOMAL PROTEIN L20 FROM AQUIFEX AEOLICUS

Template:ABSTRACT PUBMED 12368106

About this Structure

1GYZ is a Single protein structure of sequence from Aquifex aeolicus. Full experimental information is available from OCA.

Reference

NMR structure of bacterial ribosomal protein l20: implications for ribosome assembly and translational control., Raibaud S, Lebars I, Guillier M, Chiaruttini C, Bontems F, Rak A, Garber M, Allemand F, Springer M, Dardel F, J Mol Biol. 2002 Oct 11;323(1):143-51. PMID:12368106

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