1gz0

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{{STRUCTURE_1gz0| PDB=1gz0 | SCENE= }}
{{STRUCTURE_1gz0| PDB=1gz0 | SCENE= }}
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'''23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB'''
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===23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB===
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==Overview==
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In Escherichia coli, RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. The crystal structure of this 2'O-methyltransferase has been determined at 2.5 A resolution. RlmB consists of an N-terminal domain connected by a flexible extended linker to a catalytic C-terminal domain and forms a dimer in solution. The C-terminal domain displays a divergent methyltransferase fold with a unique knotted region, and lacks the classic AdoMet binding site features. The N-terminal domain is similar to ribosomal proteins L7 and L30, suggesting a role in 23S rRNA recognition. The conserved residues in this novel family of 2'O-methyltransferases cluster in the knotted region, suggesting the location of the catalytic and AdoMet binding sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 12377117 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12377117}}
==About this Structure==
==About this Structure==
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[[Category: Montreal-kingston bacterial structural genomics initiative]]
[[Category: Montreal-kingston bacterial structural genomics initiative]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:11:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:20:31 2008''

Revision as of 03:20, 1 July 2008

Image:1gz0.png

Template:STRUCTURE 1gz0

23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB

Template:ABSTRACT PUBMED 12377117

About this Structure

1GZ0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot., Michel G, Sauve V, Larocque R, Li Y, Matte A, Cygler M, Structure. 2002 Oct;10(10):1303-15. PMID:12377117

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