1gzt

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[[Image:1gzt.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1gzt| PDB=1gzt | SCENE= }}
{{STRUCTURE_1gzt| PDB=1gzt | SCENE= }}
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'''PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE'''
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===PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE===
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==Overview==
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Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Le(a)) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics.
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The line below this paragraph, {{ABSTRACT_PUBMED_12415289}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12415289 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12415289}}
==About this Structure==
==About this Structure==
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[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Sugar-binding protein]]
[[Category: Sugar-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:13:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:23:06 2008''

Revision as of 03:23, 1 July 2008

Image:1gzt.png

Template:STRUCTURE 1gzt

PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE

Template:ABSTRACT PUBMED 12415289

About this Structure

1GZT is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients., Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A, Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:12415289

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