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1gzz

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{{STRUCTURE_1gzz| PDB=1gzz | SCENE= }}
{{STRUCTURE_1gzz| PDB=1gzz | SCENE= }}
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'''HUMAN INSULIN-LIKE GROWTH FACTOR; HAMBURG DATA'''
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===HUMAN INSULIN-LIKE GROWTH FACTOR; HAMBURG DATA===
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==Overview==
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Human insulin-like growth factors I and II (hIGF-I, hIGF-II) are potent stimulators of cell and growth processes. They display high sequence similarity to both the A and B chains of insulin but contain an additional connecting C-domain, which reflects their secretion without specific packaging or precursor conversion. IGFs also have an extension at the C-terminus known as the D-domain. This paper describes four homologous hIGF-1 structures, obtained from crystals grown in the presence of the detergent SB12, which reveal additional detail in the C- and D-domains. Two different detergent binding modes observed in the crystals may reflect different hIGF-I biological properties such as the interaction with IGF binding proteins and self-aggregation. While the helical core of hIGF-I is very similar to that in insulin, there are distinct differences in the region of hIGF-I corresponding to the insulin B chain C-terminus, residues B25-B30. In hIGF-I, these residues (24-29) and the following C-domain form an extensive loop protruding 20 A from the core, which results in a substantially different conformation for the receptor binding epitope in hIGF-I compared to insulin. One notable feature of the structures presented here is demonstration of peptide-bond cleavage between Ser35 and Arg36 resulting in an apparent gap between residues 35 and 39. The equivalent region of proinsulin is involved in hormone processing demanding a reassessment of the structural integrity of hIGF-I in relation to its biological function.
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(as it appears on PubMed at http://www.pubmed.gov), where 12135360 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12135360}}
==About this Structure==
==About this Structure==
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[[Category: Insulin family]]
[[Category: Insulin family]]
[[Category: Plasma]]
[[Category: Plasma]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:14:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:23:38 2008''

Revision as of 03:23, 1 July 2008

Image:1gzz.png

Template:STRUCTURE 1gzz

HUMAN INSULIN-LIKE GROWTH FACTOR; HAMBURG DATA

Template:ABSTRACT PUBMED 12135360

About this Structure

1GZZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural origins of the functional divergence of human insulin-like growth factor-I and insulin., Brzozowski AM, Dodson EJ, Dodson GG, Murshudov GN, Verma C, Turkenburg JP, de Bree FM, Dauter Z, Biochemistry. 2002 Jul 30;41(30):9389-97. PMID:12135360

Page seeded by OCA on Tue Jul 1 06:23:38 2008

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