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1h0d

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[[Image:1h0d.gif|left|200px]]
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{{Seed}}
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[[Image:1h0d.png|left|200px]]
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{{STRUCTURE_1h0d| PDB=1h0d | SCENE= }}
{{STRUCTURE_1h0d| PDB=1h0d | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN IN COMPLEX WITH FAB FRAGMENT OF ITS MONOCLONAL ANTIBODY MAB 26-2F'''
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===CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN IN COMPLEX WITH FAB FRAGMENT OF ITS MONOCLONAL ANTIBODY MAB 26-2F===
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==Overview==
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The murine monoclonal antibody 26-2F neutralizes the angiogenic and ribonucleolytic activities of human angiogenin (ANG) and is highly effective in preventing the establishment and metastatic dissemination of human tumors in athymic mice. Here we report a 2.0 A resolution crystal structure for the complex of ANG with the Fab fragment of 26-2F that reveals the detailed interactions between ANG and the complementarity-determining regions (CDRs) of the antibody. Surprisingly, Fab binding induces a dramatic conformational change in the cell binding region of ANG at the opposite end of the molecule from the combining site; crosslinking experiments indicate that this rearrangement also occurs in solution. The ANG-Fab complex structure should be invaluable for designing maximally humanized versions of 26-2F for potential clinical use.
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The line below this paragraph, {{ABSTRACT_PUBMED_12842050}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12842050 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12842050}}
==About this Structure==
==About this Structure==
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[[Category: Antibody]]
[[Category: Antibody]]
[[Category: Ribonuclease]]
[[Category: Ribonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:15:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:24:47 2008''

Revision as of 03:24, 1 July 2008

Image:1h0d.png

Template:STRUCTURE 1h0d

CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN IN COMPLEX WITH FAB FRAGMENT OF ITS MONOCLONAL ANTIBODY MAB 26-2F

Template:ABSTRACT PUBMED 12842050

About this Structure

1H0D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human angiogenin in complex with an antitumor neutralizing antibody., Chavali GB, Papageorgiou AC, Olson KA, Fett JW, Hu G, Shapiro R, Acharya KR, Structure. 2003 Jul;11(7):875-85. PMID:12842050

Page seeded by OCA on Tue Jul 1 06:24:47 2008

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