1h0h

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[[Image:1h0h.gif|left|200px]]
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{{Seed}}
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[[Image:1h0h.png|left|200px]]
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{{STRUCTURE_1h0h| PDB=1h0h | SCENE= }}
{{STRUCTURE_1h0h| PDB=1h0h | SCENE= }}
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'''TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS'''
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===TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS===
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==Overview==
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Desulfovibrio gigas formate dehydrogenase is the first representative of a tungsten-containing enzyme from a mesophile that has been structurally characterized. It is a heterodimer of 110 and 24 kDa subunits. The large subunit, homologous to E. coli FDH-H and to D. desulfuricans nitrate reductase, harbors the W site and one [4Fe-4S] center. No small subunit ortholog containing three [4Fe-4S] clusters has been reported. The structural homology with E. coli FDH-H shows that the essential residues (SeCys158, His159, and Arg407) at the active site are conserved. The active site is accessible via a positively charged tunnel, while product release may be facilitated, for H(+) by buried waters and protonable amino acids and for CO(2) through a hydrophobic channel.
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(as it appears on PubMed at http://www.pubmed.gov), where 12220497 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12220497}}
==About this Structure==
==About this Structure==
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[[Category: Selenocysteine]]
[[Category: Selenocysteine]]
[[Category: Tungsten selenium formate dehydrogenase]]
[[Category: Tungsten selenium formate dehydrogenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:24:53 2008''

Revision as of 03:24, 1 July 2008

Image:1h0h.png

Template:STRUCTURE 1h0h

TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS

Template:ABSTRACT PUBMED 12220497

About this Structure

1H0H is a Protein complex structure of sequences from Desulfovibrio gigas. Full crystallographic information is available from OCA.

Reference

Gene sequence and the 1.8 A crystal structure of the tungsten-containing formate dehydrogenase from Desulfovibrio gigas., Raaijmakers H, Macieira S, Dias JM, Teixeira S, Bursakov S, Huber R, Moura JJ, Moura I, Romao MJ, Structure. 2002 Sep;10(9):1261-72. PMID:12220497

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