1h0l

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{{Seed}}
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{{STRUCTURE_1h0l| PDB=1h0l | SCENE= }}
{{STRUCTURE_1h0l| PDB=1h0l | SCENE= }}
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'''HUMAN PRION PROTEIN 121-230 M166C/E221C'''
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===HUMAN PRION PROTEIN 121-230 M166C/E221C===
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==Overview==
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The nuclear magnetic resonance structure of the globular domain with residues 121-230 of a variant human prion protein with two disulfide bonds, hPrP(M166C/E221C), shows the same global fold as wild-type hPrP(121-230). It contains three alpha-helices of residues 144-154, 173-194 and 200-228, an anti-parallel beta-sheet of residues 128-131 and 161-164, and the disulfides Cys166-Cys221 and Cys179-Cys214. The engineered extra disulfide bond in the presumed "protein X"-binding site is accommodated with slight, strictly localized conformational changes. High compatibility of hPrP with insertion of a second disulfide bridge in the protein X epitope was further substantiated by model calculations with additional variant structures. The ease with which the hPrP structure can accommodate a variety of locations for a second disulfide bond within the presumed protein X-binding epitope suggests a functional role for the extensive perturbation by a natural second disulfide bond of the corresponding region in the human doppel protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 12547204 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12547204}}
==About this Structure==
==About this Structure==
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1H0L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA].
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1H0L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA].
==Reference==
==Reference==
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[[Category: Prion protein]]
[[Category: Prion protein]]
[[Category: Repeat]]
[[Category: Repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:15:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:25:10 2008''

Revision as of 03:25, 1 July 2008

Image:1h0l.png

Template:STRUCTURE 1h0l

HUMAN PRION PROTEIN 121-230 M166C/E221C

Template:ABSTRACT PUBMED 12547204

About this Structure

1H0L is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure of a variant human prion protein with two disulfide bridges., Zahn R, Guntert P, von Schroetter C, Wuthrich K, J Mol Biol. 2003 Feb 7;326(1):225-34. PMID:12547204

Page seeded by OCA on Tue Jul 1 06:25:10 2008

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