1h0q

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{{STRUCTURE_1h0q| PDB=1h0q | SCENE= }}
{{STRUCTURE_1h0q| PDB=1h0q | SCENE= }}
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'''NMR SOLUTION STRUCTURE OF A FULLY MODIFIED LOCKED NUCLEIC ACID (LNA) HYBRIDIZED TO RNA'''
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===NMR SOLUTION STRUCTURE OF A FULLY MODIFIED LOCKED NUCLEIC ACID (LNA) HYBRIDIZED TO RNA===
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==Overview==
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LNA is a bicyclic nucleic acid analogue that contains one or more 2'-O,4'-C methylene linkage(s), which effectively locks the furanose ring in a C3'-endo conformation. We report here the NMR solution structure of a nonamer LNA:RNA hybrid and a structural characterization of a nonamer LNA:DNA hybrid, where the LNA strands are composed entirely of LNA nucleotides. This is the first structural characterization of fully modified LNA oligonucleotides. The high-resolution structure reveals that the LNA:RNA hybrid adopts an almost canonical A-type duplex morphology. The helix axis is almost straight and the duplex geometry is regular. This shows that fully modified LNA oligomers can hybridize with complementary RNA and form duplexes within the Watson-Crick framework. The LNA:DNA hybrid structurally resembles an RNA:DNA hybrid as shown by determination of deoxyribose sugar puckers and analysis of NOESY NMR spectra.
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(as it appears on PubMed at http://www.pubmed.gov), where 15149171 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15149171}}
==About this Structure==
==About this Structure==
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1H0Q is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0Q OCA].
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1H0Q is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0Q OCA].
==Reference==
==Reference==
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[[Category: Locked nucleic acid]]
[[Category: Locked nucleic acid]]
[[Category: Rna]]
[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:15:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:25:38 2008''

Revision as of 03:25, 1 July 2008

Image:1h0q.png

Template:STRUCTURE 1h0q

NMR SOLUTION STRUCTURE OF A FULLY MODIFIED LOCKED NUCLEIC ACID (LNA) HYBRIDIZED TO RNA

Template:ABSTRACT PUBMED 15149171

About this Structure

1H0Q is a Single protein structure. Full experimental information is available from OCA.

Reference

NMR studies of fully modified locked nucleic acid (LNA) hybrids: solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid., Nielsen KE, Rasmussen J, Kumar R, Wengel J, Jacobsen JP, Petersen M, Bioconjug Chem. 2004 May-Jun;15(3):449-57. PMID:15149171

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