We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1fzz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /><applet load="1fzz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fzz, resolution 1.86&Aring;" /> '''THE CRYSTAL STRUCTUR...)
Next diff →

Revision as of 13:26, 20 November 2007

Image:1fzz.gif

1fzz, resolution 1.86Å

Drag the structure with the mouse to rotate

THE CRYSTAL STRUCTURE OF THE COMPLEX OF NON-PEPTIDIC INHIBITOR ONO-6818 AND PORCINE PANCREATIC ELASTASE.

Overview

The crystal structure of a new inhibitor of human neutrophil elastase, (HNE), N-[2-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-(IRS)-1-(methylethyl)-2-oxoethy, l]-2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-ly)acetamide (ONO-6818, 1), complexed to porcine pancreatic elastase (PPE) has been determined at 1.86, A resolution. Analytical results provided evidence of a 1:1 complex in, which the electrophilic ketone of 1 covalently bound to O gamma of Ser195, at the active site of PPE. The role of the unique electron-withdrawing, ketone of 1 has been elucidated.

About this Structure

1FZZ is a Single protein structure of sequence from Sus scrofa with 681 as ligand. Active as Pancreatic elastase, with EC number 3.4.21.36 Full crystallographic information is available from OCA.

Reference

The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase., Odagaki Y, Ohmoto K, Matsuoka S, Hamanaka N, Nakai H, Toda M, Katsuya Y, Bioorg Med Chem. 2001 Mar;9(3):647-51. PMID:11310599

Page seeded by OCA on Tue Nov 20 15:34:05 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fzz"
Personal tools