1h21

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{{STRUCTURE_1h21| PDB=1h21 | SCENE= }}
{{STRUCTURE_1h21| PDB=1h21 | SCENE= }}
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'''A NOVEL IRON CENTRE IN THE SPLIT-SORET CYTOCHROME C FROM DESULFOVIBRIO DESULFURICANS ATCC 27774'''
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===A NOVEL IRON CENTRE IN THE SPLIT-SORET CYTOCHROME C FROM DESULFOVIBRIO DESULFURICANS ATCC 27774===
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==Overview==
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The facultative sulfate/nitrate-reducing bacterium Desulfovibrio desulfuricans ATCC 27774 harbours a split-Soret cytochrome c. This cytochrome is a homodimeric protein, having two bis-histidinyl c-type haems per monomer. It has an unique architecture at the haem domain: each haem has one of the coordinating histidines provided by the other monomer, and in each monomer the haems are parallel to each other, almost in van der Waals contact. This work reports the cloning and sequencing of the gene encoding for this cytochrome and shows, by transcriptional analysis, that it is more expressed in nitrate-grown cells than in sulfate-grown ones. In addition, the gene-deduced amino acid sequence revealed two new cysteine residues that could be involved in the binding of a non-haem iron centre. Indeed, the presence of a novel type of an iron-sulfur centre (possibly of the [2Fe-2S] type) was demonstrated by EPR spectroscopy, and putative models for its localization and structure in the cytochrome molecule are proposed on the basis of the so-far-known 3D crystallographic structure of the aerobically purified split-Soret cytochrome, which lacks this centre.
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(as it appears on PubMed at http://www.pubmed.gov), where 12589573 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12589573}}
==About this Structure==
==About this Structure==
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[[Category: Stacked heme arrangement]]
[[Category: Stacked heme arrangement]]
[[Category: Sulfate respiration]]
[[Category: Sulfate respiration]]
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Revision as of 03:29, 1 July 2008

Image:1h21.png

Template:STRUCTURE 1h21

A NOVEL IRON CENTRE IN THE SPLIT-SORET CYTOCHROME C FROM DESULFOVIBRIO DESULFURICANS ATCC 27774

Template:ABSTRACT PUBMED 12589573

About this Structure

1H21 is a Single protein structure of sequence from Desulfovibrio desulfuricans. This structure supersedes the now removed PDB entry 1ddc. Full crystallographic information is available from OCA.

Reference

A novel iron centre in the split-Soret cytochrome c from Desulfovibrio desulfuricans ATCC 27774., Abreu IA, Lourenco AI, Xavier AV, LeGall J, Coelho AV, Matias PM, Pinto DM, Armenia Carrondo M, Teixeira M, Saraiva LM, J Biol Inorg Chem. 2003 Feb;8(3):360-70. Epub 2002 Dec 19. PMID:12589573

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