1h2c

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{{STRUCTURE_1h2c| PDB=1h2c | SCENE= }}
{{STRUCTURE_1h2c| PDB=1h2c | SCENE= }}
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'''EBOLA VIRUS MATRIX PROTEIN VP40 N-TERMINAL DOMAIN IN COMPLEX WITH RNA (HIGH-RESOLUTION VP40[55-194] VARIANT).'''
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===EBOLA VIRUS MATRIX PROTEIN VP40 N-TERMINAL DOMAIN IN COMPLEX WITH RNA (HIGH-RESOLUTION VP40[55-194] VARIANT).===
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==Overview==
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The Ebola virus membrane-associated matrix protein VP40 is thought to be crucial for assembly and budding of virus particles. Here we present the crystal structure of a disk-shaped octameric form of VP40 formed by four antiparallel homodimers of the N-terminal domain. The octamer binds an RNA triribonucleotide containing the sequence 5'-U-G-A-3' through its inner pore surface, and its oligomerization and RNA binding properties are facilitated by two conformational changes when compared to monomeric VP40. The selective RNA interaction stabilizes the ring structure and confers in vitro SDS resistance to octameric VP40. SDS-resistant octameric VP40 is also found in Ebola virus-infected cells, which suggests that VP40 has an additional function in the life cycle of the virus besides promoting virus assembly and budding off the plasma membrane.
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(as it appears on PubMed at http://www.pubmed.gov), where 12679020 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12679020}}
==About this Structure==
==About this Structure==
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[[Category: Filovirus]]
[[Category: Filovirus]]
[[Category: Matrix protein vp40]]
[[Category: Matrix protein vp40]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:20:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:30:33 2008''

Revision as of 03:30, 1 July 2008

Image:1h2c.png

Template:STRUCTURE 1h2c

EBOLA VIRUS MATRIX PROTEIN VP40 N-TERMINAL DOMAIN IN COMPLEX WITH RNA (HIGH-RESOLUTION VP40[55-194] VARIANT).

Template:ABSTRACT PUBMED 12679020

About this Structure

1H2C is a Protein complex structure of sequences from Ebola virus sp. and Escherichia coli. Full crystallographic information is available from OCA.

Reference

The matrix protein VP40 from Ebola virus octamerizes into pore-like structures with specific RNA binding properties., Gomis-Ruth FX, Dessen A, Timmins J, Bracher A, Kolesnikowa L, Becker S, Klenk HD, Weissenhorn W, Structure. 2003 Apr;11(4):423-33. PMID:12679020

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