1h30

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1h30.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1h30.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1h30| PDB=1h30 | SCENE= }}
{{STRUCTURE_1h30| PDB=1h30 | SCENE= }}
-
'''C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6'''
+
===C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6===
-
==Overview==
+
<!--
-
Receptor tyrosine kinases of the Axl family are activated by Gas6, the product of growth arrest-specific gene 6. Gas6-Axl signaling is implicated in cell survival, adhesion, and migration. The receptor-binding site of Gas6 is located within a C-terminal pair of laminin G-like (LG) domains that do not resemble any other receptor tyrosine kinase ligand. We report the crystal structure at 2.2-A resolution of a Gas6 fragment spanning both LG domains (Gas6-LG). The structure reveals a V-shaped arrangement of LG domains strengthened by an interdomain calcium-binding site. LG2 of Gas6-LG contains two unusual features: an alpha-helix cradled by one edge of the LG beta-sandwich and a conspicuous patch of surface-exposed hydrophobic residues. Mutagenesis of some residues in this patch reduces Gas6-LG binding to the extracellular domain of Axl as well as Axl activation in glioblastoma cells, identifying a component of the receptor-binding site of Gas6.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12218057}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12218057 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12218057}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Laminin g-like domain]]
[[Category: Laminin g-like domain]]
[[Category: Vitamin k-dependent protein]]
[[Category: Vitamin k-dependent protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:21:51 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:32:24 2008''

Revision as of 03:32, 1 July 2008

Image:1h30.png

Template:STRUCTURE 1h30

C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6

Template:ABSTRACT PUBMED 12218057

About this Structure

1H30 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains., Sasaki T, Knyazev PG, Cheburkin Y, Gohring W, Tisi D, Ullrich A, Timpl R, Hohenester E, J Biol Chem. 2002 Nov 15;277(46):44164-70. Epub 2002 Sep 5. PMID:12218057

Page seeded by OCA on Tue Jul 1 06:32:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h30"
Personal tools