1h3i

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{{STRUCTURE_1h3i| PDB=1h3i | SCENE= }}
{{STRUCTURE_1h3i| PDB=1h3i | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE HISTONE METHYLTRANSFERASE SET7/9'''
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===CRYSTAL STRUCTURE OF THE HISTONE METHYLTRANSFERASE SET7/9===
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==Overview==
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Methylation of lysine residues in the N-terminal tails of histones is thought to represent an important component of the mechanism that regulates chromatin structure. The evolutionarily conserved SET domain occurs in most proteins known to possess histone lysine methyltransferase activity. We present here the crystal structure of a large fragment of human SET7/9 that contains a N-terminal beta-sheet domain as well as the conserved SET domain. Mutagenesis identifies two residues in the C terminus of the protein that appear essential for catalytic activity toward lysine-4 of histone H3. Furthermore, we show how the cofactor AdoMet binds to this domain and present biochemical data supporting the role of invariant residues in catalysis, binding of AdoMet, and interactions with the peptide substrate.
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(as it appears on PubMed at http://www.pubmed.gov), where 12372304 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12372304}}
==About this Structure==
==About this Structure==
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[[Category: Methyltransferase]]
[[Category: Methyltransferase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:23:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:33:52 2008''

Revision as of 03:33, 1 July 2008

Image:1h3i.png

Template:STRUCTURE 1h3i

CRYSTAL STRUCTURE OF THE HISTONE METHYLTRANSFERASE SET7/9

Template:ABSTRACT PUBMED 12372304

About this Structure

1H3I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure and functional analysis of the histone methyltransferase SET7/9., Wilson JR, Jing C, Walker PA, Martin SR, Howell SA, Blackburn GM, Gamblin SJ, Xiao B, Cell. 2002 Oct 4;111(1):105-15. PMID:12372304

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