1h4i

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[[Image:1h4i.gif|left|200px]]
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{{STRUCTURE_1h4i| PDB=1h4i | SCENE= }}
{{STRUCTURE_1h4i| PDB=1h4i | SCENE= }}
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'''METHYLOBACTERIUM EXTORQUENS METHANOL DEHYDROGENASE'''
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===METHYLOBACTERIUM EXTORQUENS METHANOL DEHYDROGENASE===
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==Overview==
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BACKGROUND: Methanol dehydrogenase (MDH) is a bacterial periplasmic quinoprotein; it has pyrrolo-quinoline quinone (PQQ) as its prosthetic group, requires Ca2+ for activity and uses cytochrome cL as its electron acceptor. Low-resolution structures of MDH have already been determined. RESULTS: The structure of the alpha 2 beta 2 tetramer of MDH from Methylobacterium extorquens has now been determined at 1.94 A with an R-factor of 19.85%. CONCLUSIONS: The alpha-subunit of MDH has an eight-fold radial symmetry, with its eight beta-sheets stabilized by a novel tryptophan docking motif. The PQQ in the active site is held in place by a coplanar tryptophan and by a novel disulphide ring formed between adjacent cysteines which are bonded by an unusual non-planar trans peptide bond. One of the carbonyl oxygens of PQQ is bonded to the Ca2+, probably facilitating attack on the substrate, and the other carbonyl oxygen is out of the plane of the ring, confirming the presence of the predicted free-radical semiquinone form of the prosthetic group.
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(as it appears on PubMed at http://www.pubmed.gov), where 7735834 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7735834}}
==About this Structure==
==About this Structure==
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[[Category: Dehydrogenase]]
[[Category: Dehydrogenase]]
[[Category: Quinoprotein]]
[[Category: Quinoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:25:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:36:39 2008''

Revision as of 03:36, 1 July 2008

Image:1h4i.png

Template:STRUCTURE 1h4i

METHYLOBACTERIUM EXTORQUENS METHANOL DEHYDROGENASE

Template:ABSTRACT PUBMED 7735834

About this Structure

1H4I is a Protein complex structure of sequences from Methylobacterium extorquens. Full crystallographic information is available from OCA.

Reference

The refined structure of the quinoprotein methanol dehydrogenase from Methylobacterium extorquens at 1.94 A., Ghosh M, Anthony C, Harlos K, Goodwin MG, Blake C, Structure. 1995 Feb 15;3(2):177-87. PMID:7735834

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