1h4u

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{{STRUCTURE_1h4u| PDB=1h4u | SCENE= }}
{{STRUCTURE_1h4u| PDB=1h4u | SCENE= }}
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'''DOMAIN G2 OF MOUSE NIDOGEN-1'''
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===DOMAIN G2 OF MOUSE NIDOGEN-1===
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==Overview==
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Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. Here, we report the crystal structure of the mouse nidogen-1 G2 fragment, which contains binding sites for collagen IV and perlecan. The structure is composed of an EGF-like domain and an 11-stranded beta-barrel with a central helix. The beta-barrel domain has unexpected similarity to green fluorescent protein. A large surface patch on the beta-barrel is strikingly conserved in all metazoan nidogens. Site-directed mutagenesis demonstrates that the conserved residues are involved in perlecan binding.
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{{ABSTRACT_PUBMED_11427896}}
==About this Structure==
==About this Structure==
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[[Category: Timpl, R.]]
[[Category: Timpl, R.]]
[[Category: Extracellular matrix protein]]
[[Category: Extracellular matrix protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:37:35 2008''

Revision as of 03:37, 1 July 2008

Image:1h4u.png

Template:STRUCTURE 1h4u

DOMAIN G2 OF MOUSE NIDOGEN-1

Template:ABSTRACT PUBMED 11427896

About this Structure

1H4U is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1., Hopf M, Gohring W, Ries A, Timpl R, Hohenester E, Nat Struct Biol. 2001 Jul;8(7):634-40. PMID:11427896

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