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1h59

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[[Image:1h59.gif|left|200px]]
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{{Seed}}
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[[Image:1h59.png|left|200px]]
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{{STRUCTURE_1h59| PDB=1h59 | SCENE= }}
{{STRUCTURE_1h59| PDB=1h59 | SCENE= }}
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'''COMPLEX OF IGFBP-5 WITH IGF-I'''
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===COMPLEX OF IGFBP-5 WITH IGF-I===
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==Overview==
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Insulin-like growth factors (IGFs) are key regulators of cell proliferation, differentiation and transformation, and are thus pivotal in cancer, especially breast, prostate and colon neoplasms. They are also important in many neurological and bone disorders. Their potent mitogenic and anti-apoptotic actions depend primarily on their availability to bind to the cell surface IGF-I receptor. In circulation and interstitial fluids, IGFs are largely unavailable as they are tightly associated with IGF-binding proteins (IGFBPs) and are released after IGFBP proteolysis. Here we report the 2.1 A crystal structure of the complex of IGF-I bound to the N-terminal IGF-binding domain of IGFBP-5 (mini-IGFBP-5), a prototype interaction for all N-terminal domains of the IGFBP family. The principal interactions in the complex comprise interlaced hydrophobic side chains that protrude from both IGF-I and the IGFBP-5 fragment and a surrounding network of polar interactions. A solvent-exposed hydrophobic patch is located on the IGF-I pole opposite to the mini-IGFBP-5 binding region and marks the IGF-I receptor binding site.
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The line below this paragraph, {{ABSTRACT_PUBMED_11447105}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11447105 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11447105}}
==About this Structure==
==About this Structure==
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[[Category: Insulin]]
[[Category: Insulin]]
[[Category: Insulin-like growth factor]]
[[Category: Insulin-like growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:26:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:38:43 2008''

Revision as of 03:38, 1 July 2008

Image:1h59.png

Template:STRUCTURE 1h59

COMPLEX OF IGFBP-5 WITH IGF-I

Template:ABSTRACT PUBMED 11447105

About this Structure

1H59 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5., Zeslawski W, Beisel HG, Kamionka M, Kalus W, Engh RA, Huber R, Lang K, Holak TA, EMBO J. 2001 Jul 16;20(14):3638-44. PMID:11447105

Page seeded by OCA on Tue Jul 1 06:38:43 2008

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