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1h5p

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[[Image:1h5p.jpg|left|200px]]
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{{STRUCTURE_1h5p| PDB=1h5p | SCENE= }}
{{STRUCTURE_1h5p| PDB=1h5p | SCENE= }}
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'''SOLUTION STRUCTURE OF THE HUMAN SP100B SAND DOMAIN BY HETERONUCLEAR NMR.'''
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===SOLUTION STRUCTURE OF THE HUMAN SP100B SAND DOMAIN BY HETERONUCLEAR NMR.===
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==Overview==
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The SAND domain is a conserved sequence motif found in a number of nuclear proteins, including the Sp100 family and NUDR. These are thought to play important roles in chromatin-dependent transcriptional regulation and are linked to many diseases. We have determined the three-dimensional (3D) structure of the SAND domain from Sp100b. The structure represents a novel alpha/beta fold, in which a conserved KDWK sequence motif is found within an alpha-helical, positively charged surface patch. For NUDR, the SAND domain is shown to be sufficient to mediate DNA binding. Using mutational analyses and chemical shift perturbation experiments, the DNA binding surface is mapped to the alpha-helical region encompassing the KDWK motif. The DNA binding activity of wild type and mutant proteins in vitro correlates with transcriptional regulation activity of full length NUDR in vivo. The evolutionarily conserved SAND domain defines a new DNA binding fold that is involved in chromatin-associated transcriptional regulation.
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(as it appears on PubMed at http://www.pubmed.gov), where 11427895 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11427895}}
==About this Structure==
==About this Structure==
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1H5P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H5P OCA].
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1H5P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H5P OCA].
==Reference==
==Reference==
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[[Category: Sp100b]]
[[Category: Sp100b]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:27:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:39:51 2008''

Revision as of 03:39, 1 July 2008

Image:1h5p.png

Template:STRUCTURE 1h5p

SOLUTION STRUCTURE OF THE HUMAN SP100B SAND DOMAIN BY HETERONUCLEAR NMR.

Template:ABSTRACT PUBMED 11427895

About this Structure

1H5P is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation., Bottomley MJ, Collard MW, Huggenvik JI, Liu Z, Gibson TJ, Sattler M, Nat Struct Biol. 2001 Jul;8(7):626-33. PMID:11427895

Page seeded by OCA on Tue Jul 1 06:39:51 2008

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