1h67

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{{STRUCTURE_1h67| PDB=1h67 | SCENE= }}
{{STRUCTURE_1h67| PDB=1h67 | SCENE= }}
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'''NMR STRUCTURE OF THE CH DOMAIN OF CALPONIN'''
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===NMR STRUCTURE OF THE CH DOMAIN OF CALPONIN===
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==Overview==
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Calponin is involved in the regulation of contractility and organization of the actin cytoskeleton in smooth muscle cells. It is the archetypal member of the calponin homology (CH) domain family of actin binding proteins that includes cytoskeletal linkers such as alpha-actinin, spectrin, and dystrophin, and regulatory proteins including VAV, IQGAP, and calponin. We have determined the first structure of a CH domain from a single CH domain-containing protein, that of calponin, and have fitted the NMR-derived coordinates to the 3D-helical reconstruction of the F-actin:calponin complex using cryo-electron microscopy. The tertiary fold of this single CH domain is typical of, yet significantly different from, those of the CH domains that occur in tandem pairs to form high-affinity ABDs in other proteins. We thus provide a structural insight into the mode of interaction between F-actin and CH domain-containing proteins.
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{{ABSTRACT_PUBMED_11839310}}
==About this Structure==
==About this Structure==
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1H67 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H67 OCA].
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1H67 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H67 OCA].
==Reference==
==Reference==
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[[Category: Calponin homology domain]]
[[Category: Calponin homology domain]]
[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:41:28 2008''

Revision as of 03:41, 1 July 2008

Image:1h67.png

Template:STRUCTURE 1h67

NMR STRUCTURE OF THE CH DOMAIN OF CALPONIN

Template:ABSTRACT PUBMED 11839310

About this Structure

1H67 is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin:calponin., Bramham J, Hodgkinson JL, Smith BO, Uhrin D, Barlow PN, Winder SJ, Structure. 2002 Feb;10(2):249-58. PMID:11839310

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