1h8a

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[[Image:1h8a.gif|left|200px]]
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{{Seed}}
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[[Image:1h8a.png|left|200px]]
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{{STRUCTURE_1h8a| PDB=1h8a | SCENE= }}
{{STRUCTURE_1h8a| PDB=1h8a | SCENE= }}
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'''CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3'''
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===CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3===
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==Overview==
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c-Myb, but not avian myeloblastosis virus (AMV) v-Myb, cooperates with C/EBP beta to regulate transcription of myeloid-specific genes. To assess the structural basis for that difference, we determined the crystal structures of complexes comprised of the c-Myb or AMV v-Myb DNA-binding domain (DBD), the C/EBP beta DBD, and a promoter DNA fragment. Within the c-Myb complex, a DNA-bound C/EBP beta interacts with R2 of c-Myb bound to a different DNA fragment; point mutations in v-Myb R2 eliminate such interaction within the v-Myb complex. GST pull-down assays, luciferase trans-activation assays, and atomic force microscopy confirmed that the interaction of c-Myb and C/EBP beta observed in crystal mimics their long range interaction on the promoter, which is accompanied by intervening DNA looping.
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The line below this paragraph, {{ABSTRACT_PUBMED_11792321}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11792321 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11792321}}
==About this Structure==
==About this Structure==
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[[Category: Transforming protein]]
[[Category: Transforming protein]]
[[Category: V-myb]]
[[Category: V-myb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:33:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:47:25 2008''

Revision as of 03:47, 1 July 2008

Image:1h8a.png

Template:STRUCTURE 1h8a

CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3

Template:ABSTRACT PUBMED 11792321

About this Structure

1H8A is a Protein complex structure of sequences from Avian myeloblastosis virus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter., Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Kimura K, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S, Ogata K, Cell. 2002 Jan 11;108(1):57-70. PMID:11792321

Page seeded by OCA on Tue Jul 1 06:47:25 2008

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