1h8e

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[[Image:1h8e.gif|left|200px]]
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{{Seed}}
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[[Image:1h8e.png|left|200px]]
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{{STRUCTURE_1h8e| PDB=1h8e | SCENE= }}
{{STRUCTURE_1h8e| PDB=1h8e | SCENE= }}
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'''(ADP.ALF4)2(ADP.SO4) BOVINE F1-ATPASE (ALL THREE CATALYTIC SITES OCCUPIED)'''
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===(ADP.ALF4)2(ADP.SO4) BOVINE F1-ATPASE (ALL THREE CATALYTIC SITES OCCUPIED)===
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==Overview==
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The crystal structure of a novel aluminium fluoride inhibited form of bovine mitochondrial F(1)-ATPase has been determined at 2 A resolution. In contrast to all previously determined structures of the bovine enzyme, all three catalytic sites are occupied by nucleotide. The subunit that did not bind nucleotide in previous structures binds ADP and sulfate (mimicking phosphate), and adopts a "half-closed" conformation. This structure probably represents the posthydrolysis, pre-product release step on the catalytic pathway. A catalytic scheme for hydrolysis (and synthesis) at physiological rates and a mechanism for the ATP-driven rotation of the gamma subunit are proposed based on the crystal structures of the bovine enzyme.
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The line below this paragraph, {{ABSTRACT_PUBMED_11509182}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11509182 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11509182}}
==About this Structure==
==About this Structure==
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[[Category: F1-atpase]]
[[Category: F1-atpase]]
[[Category: F1fo atp synthase]]
[[Category: F1fo atp synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:34:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:47:55 2008''

Revision as of 03:47, 1 July 2008

Image:1h8e.png

Template:STRUCTURE 1h8e

(ADP.ALF4)2(ADP.SO4) BOVINE F1-ATPASE (ALL THREE CATALYTIC SITES OCCUPIED)

Template:ABSTRACT PUBMED 11509182

About this Structure

1H8E is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis., Menz RI, Walker JE, Leslie AG, Cell. 2001 Aug 10;106(3):331-41. PMID:11509182

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