1h8f

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{{STRUCTURE_1h8f| PDB=1h8f | SCENE= }}
{{STRUCTURE_1h8f| PDB=1h8f | SCENE= }}
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'''GLYCOGEN SYNTHASE KINASE 3 BETA.'''
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===GLYCOGEN SYNTHASE KINASE 3 BETA.===
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==Overview==
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Glycogen synthase kinase 3 beta (GSK3 beta) plays a key role in insulin and Wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event. The crystal structure of human GSK3 beta shows a catalytically active conformation in the absence of activation-segment phosphorylation, with the sulphonate of a buffer molecule bridging the activation-segment and N-terminal domain in the same way as the phosphate group of the activation-segment phospho-Ser/Thr in other kinases. The location of this oxyanion binding site in the substrate binding cleft indicates direct coupling of P+4 phosphate-primed substrate binding and catalytic activation, explains the ability of GSK3 beta to processively hyperphosphorylate substrates with Ser/Thr pentad-repeats, and suggests a mechanism for autoinhibition in which the phosphorylated N terminus binds as a competitive pseudosubstrate with phospho-Ser 9 occupying the P+4 site.
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The line below this paragraph, {{ABSTRACT_PUBMED_11440715}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11440715 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11440715}}
==About this Structure==
==About this Structure==
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[[Category: Insulin pathway]]
[[Category: Insulin pathway]]
[[Category: Kinase]]
[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:34:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:48:02 2008''

Revision as of 03:48, 1 July 2008

Image:1h8f.png


PDB ID 1h8f

Drag the structure with the mouse to rotate
1h8f, resolution 2.80Å ()
Ligands:
Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



GLYCOGEN SYNTHASE KINASE 3 BETA.

Template:ABSTRACT PUBMED 11440715

About this Structure

1H8F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition., Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH, Cell. 2001 Jun 15;105(6):721-32. PMID:11440715

Page seeded by OCA on Tue Jul 1 06:48:02 2008

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