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1h8p

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[[Image:1h8p.jpg|left|200px]]
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{{STRUCTURE_1h8p| PDB=1h8p | SCENE= }}
{{STRUCTURE_1h8p| PDB=1h8p | SCENE= }}
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'''BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE'''
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===BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE===
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==Overview==
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Bovine seminal plasma PDC-109 binds to sperm surface choline lipids and promotes sperm capacitation by stimulating the efflux of cholesterol and phospholipids. The structure of PDC-109 with bound phosphorylcholine was solved using MAD data of a single platinum site. Its two globular (40 x 50 x 20 A(3)) Fn2 domains are linked and clustered by a short polypeptide. The choline binding sites lie at the same face of the molecule. Phosphorylcholine binds to the Fn2 domains through a cation-pi interaction between the quaternary ammonium group and a core tryptophan, plus hydrogen bonding between hydroxyls of exposed tyrosines and the phosphate group. The structure of the PDC-109-oPC complex provides a structural ground for the sperm membrane-coating mechanism underlying PDC-109-induced capacitation.
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(as it appears on PubMed at http://www.pubmed.gov), where 11937055 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11937055}}
==About this Structure==
==About this Structure==
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[[Category: Wah, D A.]]
[[Category: Wah, D A.]]
[[Category: Phosphorylcholine-binding protein]]
[[Category: Phosphorylcholine-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:34:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:49:21 2008''

Revision as of 03:49, 1 July 2008

Image:1h8p.png

Template:STRUCTURE 1h8p

BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE

Template:ABSTRACT PUBMED 11937055

About this Structure

1H8P is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex., Wah DA, Fernandez-Tornero C, Sanz L, Romero A, Calvete JJ, Structure. 2002 Apr;10(4):505-14. PMID:11937055

Page seeded by OCA on Tue Jul 1 06:49:21 2008

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