1h9d

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[[Image:1h9d.gif|left|200px]]
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{{STRUCTURE_1h9d| PDB=1h9d | SCENE= }}
{{STRUCTURE_1h9d| PDB=1h9d | SCENE= }}
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'''AML1/CBF-BETA/DNA COMPLEX'''
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===AML1/CBF-BETA/DNA COMPLEX===
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==Overview==
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We have determined the structure, at 2.6 A resolution, of the AML1 (Runx1) Runt domain--CBF beta--DNA ternary complex, the most common target for mutations in human leukemia. The structure reveals that the Runt domain DNA binding mechanism is unique within the p53 family of transcription factors. The extended C-terminal 'tail' and 'wing' elements adopt a specific DNA-bound conformation that clamps the phosphate backbone between the major and minor grooves of the distorted B-form DNA recognition site. Furthermore, the extended 'tail' mediates most of the NF-kappa B/Rel-like base-specific contacts in the major groove. The structure clearly explains the molecular basis for the loss of DNA binding function of the Runt domain--CBF beta complex as a consequence of the human disease-associated mutations in leukemogenesis and cleidocranial dysplasia.
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The line below this paragraph, {{ABSTRACT_PUBMED_11276260}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11276260 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11276260}}
==Disease==
==Disease==
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[[Category: Warren, A J.]]
[[Category: Warren, A J.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:36:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:48:59 2008''

Revision as of 04:49, 1 July 2008

Image:1h9d.png

Template:STRUCTURE 1h9d

Contents

AML1/CBF-BETA/DNA COMPLEX

Template:ABSTRACT PUBMED 11276260

Disease

Known disease associated with this structure: Leukemia, acute myeloid OMIM:[151385], Platelet disorder, familial, with associated myeloid malignancy OMIM:[151385], Rheumatoid arthritis, susceptibility to OMIM:[151385], Myeloid leukemia, acute, M4Eo subtype OMIM:[121360]

About this Structure

1H9D is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp., Bravo J, Li Z, Speck NA, Warren AJ, Nat Struct Biol. 2001 Apr;8(4):371-8. PMID:11276260

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