This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ha0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ha0.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ha0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ha0| PDB=1ha0 | SCENE= }}
{{STRUCTURE_1ha0| PDB=1ha0 | SCENE= }}
-
'''HEMAGGLUTININ PRECURSOR HA0'''
+
===HEMAGGLUTININ PRECURSOR HA0===
-
==Overview==
+
<!--
-
The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent surface loop adjacent to a novel cavity; cleavage results in structural rearrangements in which the nonpolar amino acids near the new amino terminus bury ionizable residues in the cavity that are implicated in the low-pH-induced conformational change. Amino acid insertions at the cleavage site in HAs of virulent avian viruses and those of viruses isolated from the recent severe outbreak of influenza in humans in Hong Kong would extend this surface loop, facilitating intracellular cleavage.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9814710}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9814710 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9814710}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Membrane-fusion precursor]]
[[Category: Membrane-fusion precursor]]
[[Category: Virus/viral protein]]
[[Category: Virus/viral protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:37:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:52:39 2008''

Revision as of 04:52, 1 July 2008

Image:1ha0.png

Template:STRUCTURE 1ha0

HEMAGGLUTININ PRECURSOR HA0

Template:ABSTRACT PUBMED 9814710

About this Structure

1HA0 is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation., Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC, Cell. 1998 Oct 30;95(3):409-17. PMID:9814710

Page seeded by OCA on Tue Jul 1 07:52:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ha0"
Personal tools