1ha0

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{{STRUCTURE_1ha0| PDB=1ha0 | SCENE= }}
{{STRUCTURE_1ha0| PDB=1ha0 | SCENE= }}
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'''HEMAGGLUTININ PRECURSOR HA0'''
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===HEMAGGLUTININ PRECURSOR HA0===
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==Overview==
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The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent surface loop adjacent to a novel cavity; cleavage results in structural rearrangements in which the nonpolar amino acids near the new amino terminus bury ionizable residues in the cavity that are implicated in the low-pH-induced conformational change. Amino acid insertions at the cleavage site in HAs of virulent avian viruses and those of viruses isolated from the recent severe outbreak of influenza in humans in Hong Kong would extend this surface loop, facilitating intracellular cleavage.
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(as it appears on PubMed at http://www.pubmed.gov), where 9814710 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9814710}}
==About this Structure==
==About this Structure==
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[[Category: Membrane-fusion precursor]]
[[Category: Membrane-fusion precursor]]
[[Category: Virus/viral protein]]
[[Category: Virus/viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:52:39 2008''

Revision as of 04:52, 1 July 2008

Image:1ha0.png

Template:STRUCTURE 1ha0

HEMAGGLUTININ PRECURSOR HA0

Template:ABSTRACT PUBMED 9814710

About this Structure

1HA0 is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation., Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC, Cell. 1998 Oct 30;95(3):409-17. PMID:9814710

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