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1ha1

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{{STRUCTURE_1ha1| PDB=1ha1 | SCENE= }}
{{STRUCTURE_1ha1| PDB=1ha1 | SCENE= }}
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'''HNRNP A1 (RBD1,2) FROM HOMO SAPIENS'''
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===HNRNP A1 (RBD1,2) FROM HOMO SAPIENS===
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==Overview==
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Heterogeneous ribonucleoprotein A1 (hnRNP A1) is an abundant eukaryotic nuclear RNA binding protein. A1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm and may modulate splice site selection. The crystal structure of A1(RBD1,2) reveals two independently-folded RNA binding domains (RBDs) connected by a flexible linker. Both RBDs are structurally homologous to the U1A(RBD1), and have their RNA binding platforms oriented in an anti-parallel fashion. The anti-parallel arrangement of the A1 RNA binding platforms suggests mechanisms for RNA condensation and ways of bringing together distant RNA sequences for RNA metabolism such as splicing or transport.
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(as it appears on PubMed at http://www.pubmed.gov), where 9164463 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9164463}}
==About this Structure==
==About this Structure==
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[[Category: Rnp]]
[[Category: Rnp]]
[[Category: Rrm]]
[[Category: Rrm]]
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Revision as of 04:52, 1 July 2008

Image:1ha1.png

Template:STRUCTURE 1ha1

HNRNP A1 (RBD1,2) FROM HOMO SAPIENS

Template:ABSTRACT PUBMED 9164463

About this Structure

1HA1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 A resolution., Shamoo Y, Krueger U, Rice LM, Williams KR, Steitz TA, Nat Struct Biol. 1997 Mar;4(3):215-22. PMID:9164463

Page seeded by OCA on Tue Jul 1 07:52:45 2008

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