1ha4

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{{STRUCTURE_1ha4| PDB=1ha4 | SCENE= }}
{{STRUCTURE_1ha4| PDB=1ha4 | SCENE= }}
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'''GAMMAS CRYSTALLIN C TERMINAL DOMAIN FROM HOMO SAPIENS'''
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===GAMMAS CRYSTALLIN C TERMINAL DOMAIN FROM HOMO SAPIENS===
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==Overview==
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gammaS-crystallin is a major human lens protein found in the outer region of the eye lens, where the refractive index is low. Because crystallins are not renewed they acquire post-translational modifications that may perturb stability and solubility. In common with other members of the betagamma-crystallin superfamily, gammaS-crystallin comprises two similar beta-sheet domains. The crystal structure of the C-terminal domain of human gammaS-crystallin has been solved at 2.4 A resolution. The structure shows that in the in vitro expressed protein, the buried cysteines remain reduced. The backbone conformation of the "tyrosine corner" differs from that of other betagamma-crystallins because of deviation from the consensus sequence. The two C-terminal domains in the asymmetric unit are organized about a slightly distorted 2-fold axis to form a dimer with similar geometry to full-length two-domain family members. Two glutamines found in lattice contacts may be important for short range interactions in the lens. An asparagine known to be deamidated in human cataract is located in a highly ordered structural region.
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(as it appears on PubMed at http://www.pubmed.gov), where 11706012 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11706012}}
==About this Structure==
==About this Structure==
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[[Category: Eye lens protein]]
[[Category: Eye lens protein]]
[[Category: Gammas crystallin]]
[[Category: Gammas crystallin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:37:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:53:03 2008''

Revision as of 04:53, 1 July 2008

Image:1ha4.png

Template:STRUCTURE 1ha4

GAMMAS CRYSTALLIN C TERMINAL DOMAIN FROM HOMO SAPIENS

Template:ABSTRACT PUBMED 11706012

About this Structure

1HA4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The X-ray crystal structure of human gamma S-crystallin C-terminal domain., Purkiss AG, Bateman OA, Goodfellow JM, Lubsen NH, Slingsby C, J Biol Chem. 2002 Feb 8;277(6):4199-205. Epub 2001 Nov 8. PMID:11706012

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