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| - | [[Image:1hcf.jpg|left|200px]] | + | {{Seed}} |
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| | {{STRUCTURE_1hcf| PDB=1hcf | SCENE= }} | | {{STRUCTURE_1hcf| PDB=1hcf | SCENE= }} |
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| - | '''CRYSTAL STRUCTURE OF TRKB-D5 BOUND TO NEUROTROPHIN-4/5'''
| + | ===CRYSTAL STRUCTURE OF TRKB-D5 BOUND TO NEUROTROPHIN-4/5=== |
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| - | ==Overview==
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| - | BACKGROUND: The binding of neurotrophin ligands to their respective Trk cellular receptors initiates intracellular signals essential for the growth and survival of neurons. The site of neurotrophin binding has been located to the fifth extracellular domain of the Trk receptor, with this region regulating both the affinity and specificity of Trk receptor:neurotrophin interaction. Neurotrophin function has been implicated in a number of neurological disorders, including Alzheimer's disease and Parkinson's disease. RESULTS: We have determined the 2.7 A crystal structure of neurotrophin-4/5 bound to the neurotrophin binding domain of its high-affinity receptor TrkB (TrkB-d5). As previously seen in the interaction of nerve growth factor with TrkA, neurotrophin-4/5 forms a crosslink between two spatially distant receptor molecules. The contacts formed in the TrkB-d5:neurotrophin-4/5 complex can be divided into a conserved area similar to a region observed in the TrkA-d5:NGF complex and a second site-unique in each ligand-receptor pair-formed primarily by the ordering of the neurotrophin N terminus. CONCLUSIONS: Together, the structures of the TrkB-d5:NT-4/5 and TrkA-d5:NGF complexes confirm a consistent pattern of recognition in Trk receptor:neurotrophin complex formation. In both cases, the N terminus of the neurotrophin becomes ordered only on complex formation. This ordering appears to be directed largely by the receptor surface, with the resulting complementary surfaces providing the main determinant of receptor specificity. These features provide an explanation both for the limited crossreactivity observed between the range of neurotrophins and Trk receptors and for the high-affinity binding associated with respective ligand-receptor pairs.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_11738045}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 11738045 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_11738045}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Ngf-beta superfamily]] | | [[Category: Ngf-beta superfamily]] |
| | [[Category: Trkb receptor]] | | [[Category: Trkb receptor]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:41:45 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:59:01 2008'' |
Revision as of 04:59, 1 July 2008
Template:STRUCTURE 1hcf
CRYSTAL STRUCTURE OF TRKB-D5 BOUND TO NEUROTROPHIN-4/5
Template:ABSTRACT PUBMED 11738045
About this Structure
1HCF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5., Banfield MJ, Naylor RL, Robertson AG, Allen SJ, Dawbarn D, Brady RL, Structure. 2001 Dec;9(12):1191-9. PMID:11738045
Page seeded by OCA on Tue Jul 1 07:59:01 2008
