1he7

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{{STRUCTURE_1he7| PDB=1he7 | SCENE= }}
{{STRUCTURE_1he7| PDB=1he7 | SCENE= }}
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'''HUMAN NERVE GROWTH FACTOR RECEPTOR TRKA'''
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===HUMAN NERVE GROWTH FACTOR RECEPTOR TRKA===
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==Overview==
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Nerve growth factor (NGF) is involved in the development and maintenance of the nervous system and has been implicated as a possible therapeutic target molecule in a number of neurodegenerative diseases, especially Alzheimer's disease. NGF binds with high affinity to the extracellular region of a tyrosine kinase receptor, TrkA, which comprises three leucine-rich motifs (LRMs), flanked by two cysteine-rich clusters, followed by two immunoglobulin-like (Ig-like) domains. We have expressed the second Ig-like domain as a recombinant protein in E. coli and demonstrate that NGF binds to this domain with similar affinity to the native receptor. This domain (TrkAIg(2)) has the ability to sequester NGF in vitro, preventing NGF-induced neurite outgrowth, and in vivo, inhibiting NGF-induced plasma extravasation. We also present the three-dimensional structure of the TrkAIg(2) domain in a new crystal form, refined to 2.0 A resolution.
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{{ABSTRACT_PUBMED_11263982}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Trk-receptor]]
[[Category: Trk-receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:03:46 2008''

Revision as of 05:03, 1 July 2008

Image:1he7.png

Template:STRUCTURE 1he7

HUMAN NERVE GROWTH FACTOR RECEPTOR TRKA

Template:ABSTRACT PUBMED 11263982

About this Structure

1HE7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Identification and structure of the nerve growth factor binding site on TrkA., Robertson AG, Banfield MJ, Allen SJ, Dando JA, Mason GG, Tyler SJ, Bennett GS, Brain SD, Clarke AR, Naylor RL, Wilcock GK, Brady RL, Dawbarn D, Biochem Biophys Res Commun. 2001 Mar 23;282(1):131-41. PMID:11263982

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